ABSTRACT
This study attends to Generation Zers' volunteer tourism. It draws on self-determination and goal-setting theories to synthesize a model delineating how the interplay of internal and external environmental motivational factors reshapes green volunteering involvement amid the pandemic, leading to environmental goal attainment and persistent endeavors. The inquiry adopted an online survey-based design with data collected from 340 rising environmentalists. Results first suggest that environmental self-efficacy and social climate are positively related to green volunteering involvement, with environmental self-efficacy exhibiting a more profound effect. These relationships are also moderated by eudaimonic environmental pursuits in that the relationships remain stronger when volunteers pursue eudaimonia to a high degree. Furthermore, involvement is evident in fostering environmental goal attainment, leading to pro-environmental behaviors and advocacy. With the above findings taken together, this investigation sheds light on environmental goal attainment through volunteer tourism amid the COVID-19 turbulence. It brings to light a motivation–goal attainment–behavior model that deserves investigating.
ABSTRACT
The casino industry may have been stigmatized by its notorious image due to the negative consequences that gambling brings. Yet, they are at the forefront in combating the pandemic, taking a proactive stand to expedite corporate social responsibility (CSR) through a constellation of means in a timely manner. Moreover, the majority of research focuses on the long-term strategic CSR, leaving ad-hoc CSR initiatives that are responsive without previous planning underexplored. Proactive and prompt CSR efforts exerted by casino conglomerates hence offer researchers a case in better understanding this rarely researched area pertaining to just-in-time CSR amid a mega turbulence. Based on data collected from casino websites, social media, and other public media, we have organized their initiatives into themes germane to safeguarding their personnel and guests, giving encouragement to the society, contributing to financial charities as well as daily necessities and protective supplies, promoting safety and better quality of life during the pandemic, and more. These endeavors do make a real difference in saving lives as well as uniting the community to build up resilience to mitigate the aftermath of the crisis. These expedited CSR efforts render a new phenomenon that we refer as just-in-time CSR.
ABSTRACT
The present investigation takes a qualitative approach to explore Airbnb's Online Experience as a new virtual tourism initiative through the lens of attention restoration theory. Data were collected from tourist reviews at Airbnb's platform with an emphasis on touring services such as sightseeing and cultural immersion sessions. Our findings first point to a multitude of virtual tour experiences germane to deep immersion, authenticity, nostalgia, hedonism, past-present resonance, novelty, learning, social interaction, and escape. These stay-at-home virtual restorative experiences were infused by Airbnb's state-of-the-art platform with features such as a super host, storytelling, personalization, virtual connection, stay-at-home indulgence, and technology enablement, which ultimately transcend home as the center stage for virtual attention restoration under the COVID-19 new normal. (PsycInfo Database Record (c) 2022 APA, all rights reserved)
ABSTRACT
Background: JAK (Janus kinases) inhibitors have been proposed as a promising treatment option for the coronavirus disease-2019 (COVID-19). However, the benefits of JAK inhibitors and the optimum thereof for COVID-19 have not been adequately defined. Methods: Databases were searched from their inception dates to 17 June 2022. Eligible studies included randomized controlled trials and observational studies. Extracted data were analyzed by pairwise and network meta-analysis. The primary outcome was the coefficient of mortality. Results: Twenty-eight studies of 8,206 patients were included and assessed qualitatively (modified Jadad and Newcastle-Ottawa Scale scores). A pairwise meta-analysis revealed that JAK inhibitors effectively reduced the mortality (OR = 0.54; 95% CI: 0.46-0.63; P < 0.00001; I 2 = 32%) without increasing the risk of adverse events (OR = 1.02; 95% CI: 0.88-1.18; P = 0.79; I 2 = 12%). In a network meta-analysis, clinical efficacy benefits were seen among different types of JAK inhibitors (baricitinib, ruxolitinib, and tofacitinib) without the observation of a declined incidence of adverse events. The assessment of rank probabilities indicated that ruxolitinib presented the greatest likelihood of benefits regarding mortality and adverse events. Conclusion: JAK inhibitors appear to be a promising treatment for COVID-19 concerning reducing mortality, and they do not increase the risk of adverse events vs. standard of care. A network meta-analysis suggests that mortality benefits are associated with specific JAK inhibitors, and among these, ruxolitinib presents the greatest likelihood of having benefits for mortality and adverse events. Systematic review registration: [www.crd.york.ac.uk/prospero], identifier [CRD42022343338].
ABSTRACT
Background JAK (Janus kinases) inhibitors have been proposed as a promising treatment option for the coronavirus disease-2019 (COVID-19). However, the benefits of JAK inhibitors and the optimum thereof for COVID-19 have not been adequately defined. Methods Databases were searched from their inception dates to 17 June 2022. Eligible studies included randomized controlled trials and observational studies. Extracted data were analyzed by pairwise and network meta-analysis. The primary outcome was the coefficient of mortality. Results Twenty-eight studies of 8,206 patients were included and assessed qualitatively (modified Jadad and Newcastle–Ottawa Scale scores). A pairwise meta-analysis revealed that JAK inhibitors effectively reduced the mortality (OR = 0.54;95% CI: 0.46–0.63;P < 0.00001;I2 = 32%) without increasing the risk of adverse events (OR = 1.02;95% CI: 0.88–1.18;P = 0.79;I2 = 12%). In a network meta-analysis, clinical efficacy benefits were seen among different types of JAK inhibitors (baricitinib, ruxolitinib, and tofacitinib) without the observation of a declined incidence of adverse events. The assessment of rank probabilities indicated that ruxolitinib presented the greatest likelihood of benefits regarding mortality and adverse events. Conclusion JAK inhibitors appear to be a promising treatment for COVID-19 concerning reducing mortality, and they do not increase the risk of adverse events vs. standard of care. A network meta-analysis suggests that mortality benefits are associated with specific JAK inhibitors, and among these, ruxolitinib presents the greatest likelihood of having benefits for mortality and adverse events. Systematic review registration [www.crd.york.ac.uk/prospero], identifier [CRD42022343338].
ABSTRACT
This study involves isothermal kinetic simulation to evaluate the parameters of inhibition conditions for Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) of high-risk pathogens. This is because the new type of the 2019 novel coronavirus (2019-nCoV) is continuously spreading and the importance of public health issues. Environmental disinfection and personal wearing of masks have become important epidemic prevention measures. Selection of concentration kinetics could be estimated best for E. coli and S. aureus of pathogens, 2.74 × 104 and 105 and 2.44 × 104 and 105 colony-forming units (CFU mL-1), by isothermal micro-calorimeter (TAM Air) tests, respectively. Comparisons were made of different doses of 0-70 ppm (in 20 mL test ampoule) hypochlorous acid treatment for conducting nth-order and autocatalytic reaction simulation to evaluate the inhibition reaction parameters, which determined the autocatalytic kinetic model that was beneficially applied on the E. coli and S. aureus. We developed the inhibition reaction parameters of the pathogens, which included the activation energy (E a), the natural logarithm of pre-exponential factor (lnk 0), the enthalpy of inhibition microbial growth reaction (∆H), inhibition microbial growth, and the inhibition growth analysis. Overall, we conducted isothermal kinetic simulation to understand the antimicrobial activity effects of electrolytically generated hypochlorous acid-treated pathogenic microorganisms, which will provide reference for public health and medical-related fields for SDG3, and can contribute to ensuring human health and hygiene.
ABSTRACT
Ferroptosis is an iron-dependent mode of cell death characterized by intracellular lipid peroxide accumulation and a redox reaction imbalance. Compared with other modes of cell death, ferroptosis has specific biological and morphological features. The iron-dependent lipid peroxidation accumulation is manifested explicitly in the abnormal metabolism of intracellular lipid oxides catalyzed by excessive iron ions with the production of many reactive oxygen species and over-oxidization of polyunsaturated fatty acids. Recent studies have shown that various diseases, which include intestinal diseases and cancer, are associated with ferroptosis, but few studies are related to airway inflammatory diseases. This review provides a comprehensive analysis of the primary damage mechanisms of ferroptosis and summarizes the relationship between ferroptosis and airway inflammatory diseases. In addition to common acute and chronic airway inflammatory diseases, we also focus on the progress of research on COVID-19 in relation to ferroptosis. New therapeutic approaches and current issues to be addressed in the treatment of inflammatory airway diseases using ferroptosis are further proposed.
ABSTRACT
The present investigation takes a qualitative approach to explore Airbnb's Online Experience as a new virtual tourism initiative through the lens of attention restoration theory. Data were collected from tourist reviews at Airbnb's platform with an emphasis on touring services such as sightseeing and cultural immersion sessions. Our findings first point to a multitude of virtual tour experiences germane to deep immersion, authenticity, nostalgia, hedonism, past-present resonance, novelty, learning, social interaction, and escape. These stay-at-home virtual restorative experiences were infused by Airbnb's state-of-the-art platform with features such as a super host, storytelling, personalization, virtual connection, stay-at-home indulgence, and technology enablement, which ultimately transcend home as the center stage for virtual attention restoration under the COVID-19 new normal.
ABSTRACT
The benefits of baricitinib in coronavirus disease-2019 are inadequately defined. We performed a systematic review and meta-analysis of studies of baricitinib to determine its clinical efficacy and adverse events in patients with COVID-19. Databases were searched from their inception to September 5, 2021. The primary outcome was the coefficient of mortality. We also compared secondary indicators and adverse events between baricitinib treatment and placebo or other treatments. Twelve studies of 3564 patients were included and assessed qualitatively (modified Jadad and Newcastle-Ottawa Scale scores). Baricitinib effectively improved the mortality rate (relative risk of mortality = 0.56; 95% confidence interval: 0.46-0.69; p < 0.001; I2 = 2%), and this result was unchanged by subgroup analysis. Baricitinib improved intensive care unit admission, the requirement for invasive mechanical ventilation, and improved the oxygenation index. Data from these studies also showed that baricitinib slightly reduced the risk of adverse events. Regarding the choice of the drug dosage of baricitinib, the high-dose group appeared to have additional benefits for clinical efficacy. Our study shows that baricitinib may be a promising, safe, and effective anti-severe acute respiratory syndrome-coronavirus-2 drug candidate, with the advantages of low cost, easy production, and convenient storage.
Subject(s)
Azetidines/therapeutic use , COVID-19 Drug Treatment , Purines/therapeutic use , Pyrazoles/therapeutic use , Sulfonamides/therapeutic use , Azetidines/administration & dosage , COVID-19/mortality , Dose-Response Relationship, Drug , Humans , Purines/administration & dosage , Pyrazoles/administration & dosage , SARS-CoV-2 , Sulfonamides/administration & dosage , Treatment OutcomeABSTRACT
The COVID-19 pandemic aftermath has aggravated its traumatic effect to engender a mental health crisis. With increasingly worsened psychological wellbeing, it is the responsibility of tourism scholars and operators alike to explore how contemporary tourism offerings can enable individuals to rebuild hope and optimism through relishing tourism's restorative appeals amid rigid border lockdowns. However, it remains unclear whether tourists are able to restore themselves from staycation programs, since tourists have a tendency to favor a novel space, as opposed to a usual travel environment. To address this question, we relied upon a government-funded staycation campaign using a survey to assess a transformative process leading from travel motivation and restoration to fortifying psychological capital and wellbeing. Drawing on theories pertaining to attention restoration, psychological capital, and involvement, our findings unravel a travel transformative mechanism of staycation programs that build a linkage between travel motivation and favorable psychological outcomes amid adverse circumstances.
ABSTRACT
This study marks an early attempt to evaluate staycation incentive programs initiated by local authorities. It aims to gauge the effectiveness of staycation programs in cultivating learning opportunities and restorative benefits with an emphasis on temporal positive psychological outcomes amid this continuing pandemic. Relying on a survey-based research design, we conducted a survey with 409 local tourists in Macau, where a recent staycation initiative has attained prominent success. We then undertook the structural equation modeling test using AMOS. Results show how short local excursions could still fortify one’s psychological capital with respect to ephemeral improvement in hope, confidence, optimism, and resilience in the face of extenuating circumstances. By synthesizing a path leading from COVID-related distress to fortification of a more prepared mental state for the new normal through the staycation’s experiential benefits, this study thus puts forth a mechanism that explains why tourists/residents engage in staycation programs, as well as illuminating the psychological values associated with such activities. By answering these questions, this research improvises a three-stage process that identifies pre-trip, during-trip, and post-trip mental encounters that improve participants’ psychological capabilities, even if only temporarily. The present inquiry sheds light on a new form of sustainability: mental (or psychological) sustainability. [ABSTRACT FROM AUTHOR] Copyright of Journal of Sustainable Tourism is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)